Engel Laboratory

Developmental origins of sex differences in cancer progression and outcomes

Our research

Studying the genetic and epigenetic determinants of sex differences in melanoma progression and outcomes

Why do biological males have higher risk and worse outcomes for most non-reproductive cancers, such as melanoma? How do biological males and females differ in protective and susceptibility factors for melanoma? How does the sex chromosmome complement (XX versus XY) interact with sex hormones to establish sex differences?

We study the genetic, epigenetic and transcriptomic components that drive sex differences in mammals from early embryonic development and across the lifespan.

Our values

“While timorous knowledge stands considering, audacious ignorance hath done the deed.” - Samuel Daniel (1562-1619)

We aim to do quality science in an environment that values curious, irreverent minds. We believe that the most creative thing we can do is to ask new questions. These drive the imagination and passion that are the raw material for designing elegant, informative experiments. These values generate an environment that unlocks each individual’s potential, while fostering teamwork and a culture of continuous learning.


  • (215) 707-7611
  • Lewis Katz School of Medicine, Medical Education & Research Building, 3500 N. Broad St., Philadelphia, PA 19140
  • Enter Building 1 and take the stairs to Office 200 on Floor 2